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CD in the infarct region is the most inevitable consequence of focal cerebral ischemia ( It has been proved that iron deposition was increased in the basal ganglia, thalami, periventricular and subcortical white matter areas after severe ischemic and hypoxic brain injury (Tuo et al., 2017)

Lipid peroxidation plays a pivotal role in the pathogenesis of numerous diseases, including neurodegenerative disorders (e.g., Alzheimer's disease), cardiovascular diseases, and metabolic syndromes [54, 55]

Biotin-GSSG TFA Biotin- glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA

fMRI data also showed altered activation in brain regions tied to food reward and cravings (insula, putamen, orbitofrontal cortex)